What might work: Joseph Gordon-Levitt of course. You could call me incredibly bias but hey, it's my blog isn't it? I love me some JGL. In all honesty, he's one of the best actors out there and he proved that by carrying the anti-romantic comedy (500) Days of Summer last year. There's no doubt he'll be fantastic in this.
Seth Rogan is hilarious when given the right material. I think Rogan will benefit from having a fantastic actor like JGL to bounce off of.
It's rated R. R-rated comedies are not stuck with same boundaries that PG13 ones are. This one looks like it could deliver a lot of laughs and a lot of heart.
What might not: Weak supporting cast. I don't have a ton of faith in Anna Kendrick or Bryce Dallas Howard, but hopefully the movie will focus mostly on Rogan and Gordon-Levitt's character.
Marketing: It's hard to market a movie about the main character suffering from cancer. It could turn a lot of people off, they may want a laugh and will expect a downer.
When to see it: Opening weekend for me, as it should be for any JGL fan.
Random Thought: I loved Anna Kendrick in Up in the Air, but have yet to love her in anything else.